The Application of the Combined Corticotropin-Releasing Hormone plus Desmopressin Stimulation during Petrosal Sinus Sampling Is Both Sensitive and Specific in Differentiating Patients with Cushing’s Disease from Patients with the Occult Ectopic Adrenocorticotropin Syndrome | Zendy

S. Tsagarakis | Zendy; Dimitra A. Vassiliadi | Zendy; Ioannis Kaskarelis | Zendy; John Komninos | Zendy; Emmanouil Souvatzoglou | Zendy; N. Thalassinos | Zendy

Open Access

The Application of the Combined Corticotropin-Releasing Hormone plus Desmopressin Stimulation during Petrosal Sinus Sampling Is Both Sensitive and Specific in Differentiating Patients with Cushing’s Disease from Patients with the Occult Ectopic Adrenocorticotropin Syndrome

Author(s) -

S. Tsagarakis,

Dimitra A. Vassiliadi,

Ioannis Kaskarelis,

John Komninos,

Emmanouil Souvatzoglou,

N. Thalassinos

Publication year - 2007

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2006-2691

Subject(s) - desmopressin , medicine , stimulation , context (archaeology) , cushing's disease , occult , differential diagnosis , disease , endocrinology , pathology , paleontology , alternative medicine , biology

Although bilateral inferior petrosal sinus sampling (BIPSS) with CRH stimulation is the most accurate procedure for the differential diagnosis of ACTH-dependent Cushing's syndrome (CS), 4-15% of patients with Cushing's disease (CD) fail to demonstrate diagnostic gradients. Preliminary data suggest that a more potent stimulation by the combined administration of CRH plus desmopressin during BIPSS may provide some diagnostic advantage. A crucial issue, however, is whether such an amplified stimulation may affect the specificity of the procedure, and this was the main aim of the present study.

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