The Parathyroid/Pituitary Variant of Multiple Endocrine Neoplasia Type 1 Usually Has Causes Other thanp27Kip1Mutations | Zendy

Atsushi Ozawa | Zendy; Sunita Agarwal | Zendy; César Mateo | Zendy; A. Lee Burns | Zendy; Terri S. Rice | Zendy; Patricia A. Kennedy | Zendy; Caitlin Quigley | Zendy; William F. Simonds | Zendy; Lee S. Weinstein | Zendy; Settara C. Chandrasekharappa | Zendy; Francis S. Collins | Zendy; Allen M. Spiegel | Zendy; Stephen J. Marx | Zendy

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The Parathyroid/Pituitary Variant of Multiple Endocrine Neoplasia Type 1 Usually Has Causes Other thanp27Kip1Mutations

Author(s) -

Atsushi Ozawa,

Sunita Agarwal,

César Mateo,

A. Lee Burns,

Terri S. Rice,

Patricia A. Kennedy,

Caitlin Quigley,

William F. Simonds,

Lee S. Weinstein,

Settara C. Chandrasekharappa,

Francis S. Collins,

Allen M. Spiegel,

Stephen J. Marx

Publication year - 2007

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2006-2563

Subject(s) - men1 , multiple endocrine neoplasia , endocrinology , medicine , context (archaeology) , endocrine system , germline mutation , germline , mutation , pituitary tumors , hyperparathyroidism , biology , genetics , hormone , gene , paleontology

One variant of multiple endocrine neoplasia type 1 (MEN1) is defined by sporadic tumors of both the parathyroids and pituitary. The prevalence of identified MEN1 mutations in this variant is lower than in familial MEN1 (7% vs. 90%), suggesting different causes. Recently, one case of this variant had a germline mutation of p27(Kip1)/CDKN1B.

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