Prolonged Fasting Induces Peripheral Insulin Resistance, Which Is Not Ameliorated by High-Dose Salicylate | Zendy

Saskia N. van der Crabben | Zendy; Gideon Allick | Zendy; Mariëtte T. Ackermans | Zendy; Erik Endert | Zendy; Johannes A. Romijn | Zendy; Hans P. Sauerwein | Zendy

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Prolonged Fasting Induces Peripheral Insulin Resistance, Which Is Not Ameliorated by High-Dose Salicylate

Author(s) -

Saskia N. van der Crabben,

Gideon Allick,

Mariëtte T. Ackermans,

Erik Endert,

Johannes A. Romijn,

Hans P. Sauerwein

Publication year - 2007

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2006-2491

Subject(s) - insulin resistance , peripheral , medicine , endocrinology , insulin , peripheral resistance , heart rate , blood pressure

Elevated plasma free fatty acids, excess reactive oxygen species, inflammation, and gluco-counterregulatory hormones induce insulin resistance (IR) through activation of Jun NH(2)-terminal kinase and nuclear factor-kappaB inhibitor kappaB kinase, which leads to hyperphosphorylation of the insulin receptor substrate type 1. Aspirin blocks nuclear factor-kappaB inhibitor kappaB kinase and improves IR in type 2 diabetes mellitus.

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