Glycemic Thresholds for Activation of Counterregulatory Hormone and Symptom Responses in Islet Transplant Recipients
Author(s) -
Michael R. Rickels,
Mark H. Schutta,
Rebecca Mueller,
Shiv Kapoor,
James F. Markmann,
Ali Naji,
Karen L. Teff
Publication year - 2006
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2006-2426
Subject(s) - medicine , hypoglycemia , endocrinology , glucagon , islet , glycemic , type 1 diabetes , glucose clamp technique , epinephrine , diabetes mellitus , transplantation , hyperinsulinemic hypoglycemia , hormone , pancreatic hormone , insulin resistance
In patients with type 1 diabetes and reduced awareness of hypoglycemia, the glycemic thresholds for activation of counterregulatory hormone and symptom responses to hypoglycemia are impaired, in part due to recurrent episodes of hypoglycemia. Islet transplantation can ameliorate occurrences of hypoglycemia in these patients.
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