Thyrotropin Activates Guanosine 5′-Diphosphate/Guanosine 5′-Triphosphate Exchange on the Rate-Limiting Endocytic Catalyst, Rab5a, in Human Thyrocytes in Vivo and in Vitro | Zendy

Marie-France van den Hove | Zendy; Karine Croizet-Berger | Zendy; Donatienne Tyteca | Zendy; Charlotte Selvais | Zendy; Philippe de Diesbach | Zendy; Pierre J. Courtoy | Zendy

Open Access

Thyrotropin Activates Guanosine 5′-Diphosphate/Guanosine 5′-Triphosphate Exchange on the Rate-Limiting Endocytic Catalyst, Rab5a, in Human Thyrocytes in Vivo and in Vitro

Author(s) -

Marie-France van den Hove,

Karine Croizet-Berger,

Donatienne Tyteca,

Charlotte Selvais,

Philippe de Diesbach,

Pierre J. Courtoy

Publication year - 2007

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2006-2351

Subject(s) - internalization , endocytic cycle , endocrinology , medicine , guanosine , chemistry , endocytosis , in vitro , microbiology and biotechnology , guanine nucleotide exchange factor , in vivo , receptor , biology , biochemistry , signal transduction

We have previously reported that the TSH receptor/cAMP cascade enhances the coordinate expression of the rate-limiting endocytic catalysts, Rab5a and Rab7, which respectively promote thyroglobulin (Tg) internalization and transfer to lysosomes, thereby accelerating thyroid hormone secretion.

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