Letrozole Treatment of Precocious Puberty in Girls with the McCune-Albright Syndrome: A Pilot Study | Zendy

Penelope Feuillan | Zendy; Karim A. Calis | Zendy; Suvimol Hill | Zendy; Thomas H. Shawker | Zendy; Pamela Gehron Robey | Zendy; Michael T. Collins | Zendy

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Letrozole Treatment of Precocious Puberty in Girls with the McCune-Albright Syndrome: A Pilot Study

Author(s) -

Penelope Feuillan,

Karim A. Calis,

Suvimol Hill,

Thomas H. Shawker,

Pamela Gehron Robey,

Michael T. Collins

Publication year - 2007

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2006-2350

Subject(s) - mccune–albright syndrome , letrozole , context (archaeology) , precocious puberty , aromatase , endocrinology , medicine , estrogen , aromatase inhibitor , biology , hormone , breast cancer , paleontology , cancer

Girls with McCune-Albright syndrome (MAS) and related disorders have gonadotropin-independent precocious puberty due to estrogen secretion from ovarian cysts. Their puberty does not respond to GnRH agonist therapy, and short-acting aromatase inhibitors have had limited effectiveness.

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