Analysis of the Fc Receptor-Like-3 (FCRL3) Locus in Caucasians with Autoimmune Disorders Suggests a Complex Pattern of Disease Association | Zendy

Catherine Owen | Zendy; Hannah Kelly | Zendy; James A. Eden | Zendy; Marilyn E. Merriman | Zendy; Simon H. S. Pearce | Zendy; Tony R. Merriman | Zendy

Open Access

Analysis of the Fc Receptor-Like-3 (FCRL3) Locus in Caucasians with Autoimmune Disorders Suggests a Complex Pattern of Disease Association

Author(s) -

Catherine Owen,

Hannah Kelly,

James A. Eden,

Marilyn E. Merriman,

Simon H. S. Pearce,

Tony R. Merriman

Publication year - 2007

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2006-2183

Subject(s) - haplotype , single nucleotide polymorphism , allele , odds ratio , immunology , autoimmune disease , locus (genetics) , medicine , genotype , genetics , biology , antibody , gene

A four-marker haplotype in the 5' region of the Fc receptor-like 3 gene (markers FCRL3_3 to FCRL3_6) has been identified recently as contributing to rheumatoid arthritis (RA) susceptibility in the Japanese population. The promoter FCRL3_3*C allele also showed significant association with autoimmune thyroid disease and systemic lupus erythematosus. These findings raise the possibility that this locus may influence autoimmune disease susceptibility across many populations.

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