Open AccessEvaluating the Roles of Follicle-Stimulating Hormone Receptor Polymorphisms in Gonadal Hyperstimulation Associated with Severe Juvenile Primary Hypothyroidism
Author(s) -
Ginny L. Ryan,
Xiuyan Feng,
Catarina Brasil d’Alva,
Meilin Zhang,
Bradley J. Van Voorhis,
Emília M. Pinto,
Ana Elisa F. Kubias,
Sonir Roberto Rauber Antonini,
Ana Claudia Latrônico,
Deborah L. Segaloff
Publication year - 2007
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2006-2086
Subject(s) - endocrinology , ovarian hyperstimulation syndrome , follicle stimulating hormone receptor , medicine , biology , controlled ovarian hyperstimulation , allele , hek 293 cells , receptor , follicle stimulating hormone , pregnancy , hormone , gene , infertility , genetics , in vitro fertilisation , luteinizing hormone
Rare activating mutations of the human (h)FSHR have been reported in some women with spontaneous ovarian hyperstimulation in pregnancy, where follicular growth is inappropriately stimulated by elevated concentrations of human chorionic gonadotropin acting through the hFSHR. It is not known whether ovarian hyperstimulation in peripubertal girls with untreated primary hypothyroidism is caused by hFSHR mutations and/or influenced by hFSHR allelic variants, rendering the hFSHR more sensitive to circulating TSH.
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