Rapid Pituitary Tumor Shrinkage with Dissociation between Antiproliferative and Antisecretory Effects of a Long-Acting Octreotide in an Acromegalic Patient
Author(s) -
Eugenia Resmini,
Patrizia Dadati,
Jean-Luis Ravetti,
Gianluigi Zona,
Renato Spaziante,
Alexandru Saveanu,
P Jaquet,
Michael D. Culler,
Federico Bianchi,
Alberto Rebora,
Francesco Minuto,
Diego Ferone
Publication year - 2007
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2006-2084
Subject(s) - somatostatin , somatostatin receptor , acromegaly , octreotide , receptor , agonist , endocrinology , medicine , chemistry , receptor expression , somatostatin receptor 2 , cell growth , cancer research , biology , hormone , biochemistry , growth hormone
Criteria to define the response to somatostatin (SS) analogs (SSA) in acromegaly are based on biochemical control of the disease. However, the mechanisms of action of SSAs in inhibiting tumor growth and hormonal secretion are only partially understood, and the two effects may occur independently.
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