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Amylin has been linked to the development of hypertension in several pathological states related to hypertension and insulin resistance, although there is scant data regarding its potential mechanisms of action. The -132 G/A mutation located within an activator domain of the amylin gene's promoter was first identified in a small cohort of Spanish patients with type 2 diabetes.

Amylin and Hypertension: Association of an Amylin −G132A Gene Mutation and Hypertension in Humans and Amylin-Induced Endothelium Dysfunction in Rats