Amylin and Hypertension: Association of an Amylin −G132A Gene Mutation and Hypertension in Humans and Amylin-Induced Endothelium Dysfunction in Rats | Zendy

Anovials | Zendy; Leocadio Rodrı́guez-Mañas | Zendy; Ana Chico | Zendy; Mariam El Assar | Zendy; Sı́lvia Casas | Zendy; Ramón Gomis | Zendy

Open Access

Amylin and Hypertension: Association of an Amylin −G132A Gene Mutation and Hypertension in Humans and Amylin-Induced Endothelium Dysfunction in Rats

Author(s) -

Anovials,

Leocadio Rodrı́guez-Mañas,

Ana Chico,

Mariam El Assar,

Sı́lvia Casas,

Ramón Gomis

Publication year - 2007

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2006-1980

Subject(s) - amylin , medicine , endocrinology , diabetes mellitus , population , endothelium , endothelial dysfunction , environmental health , islet

Amylin has been linked to the development of hypertension in several pathological states related to hypertension and insulin resistance, although there is scant data regarding its potential mechanisms of action. The -132 G/A mutation located within an activator domain of the amylin gene's promoter was first identified in a small cohort of Spanish patients with type 2 diabetes.

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