Studies of the CommonDIO2Thr92Ala Polymorphism and Metabolic Phenotypes in 7342 Danish White Subjects | Zendy

Niels Grarup | Zendy; Mette K. Andersen | Zendy; Camilla Andreasen | Zendy; Anders Albrechtsen | Zendy; Knut Borch-Johnsen | Zendy; Torben Jørgensen | Zendy; Johan Auwerx | Zendy; Ole Schmitz | Zendy; Torben Hansen | Zendy; Oluf Pedersen | Zendy

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Studies of the CommonDIO2Thr92Ala Polymorphism and Metabolic Phenotypes in 7342 Danish White Subjects

Author(s) -

Niels Grarup,

Mette K. Andersen,

Camilla Andreasen,

Anders Albrechtsen,

Knut Borch-Johnsen,

Torben Jørgensen,

Johan Auwerx,

Ole Schmitz,

Torben Hansen,

Oluf Pedersen

Publication year - 2006

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2006-1958

Subject(s) - dio2 , endocrinology , medicine , biology , insulin resistance , genotype , type 2 diabetes , deiodinase , allele , polymorphism (computer science) , genetics , insulin , hormone , diabetes mellitus , gene , triiodothyronine

The type 2 iodothyronine deiodinase (D2) catalyzes the conversion of T(4) to the active form of thyroid hormone, which is a critical regulator of thermogenesis and glucose metabolism. A Thr92Ala polymorphism in the gene encoding D2 (DIO2) has been reported to associate with insulin resistance.

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