Interactions among Peroxisome Proliferator Activated Receptor-γ, Insulin Signaling Pathways, and Steroidogenic Acute Regulatory Protein in Human Ovarian Cells | Zendy

Donna SetoYoung | Zendy; Dimiter Avtanski | Zendy; Marina Strizhevsky | Zendy; Grishma Parikh | Zendy; Parini Patel | Zendy; Julia Kaplun | Zendy; Kevin Holcomb | Zendy; Zev Rosenwaks | Zendy; Leonid Poretsky | Zendy

Open Access

Interactions among Peroxisome Proliferator Activated Receptor-γ, Insulin Signaling Pathways, and Steroidogenic Acute Regulatory Protein in Human Ovarian Cells

Author(s) -

Donna SetoYoung,

Dimiter Avtanski,

Marina Strizhevsky,

Grishma Parikh,

Parini Patel,

Julia Kaplun,

Kevin Holcomb,

Zev Rosenwaks,

Leonid Poretsky

Publication year - 2007

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2006-1935

Subject(s) - endocrinology , medicine , polycystic ovary , peroxisome proliferator activated receptor , rosiglitazone , insulin , insulin receptor substrate , biology , receptor , insulin receptor , chemistry , insulin resistance

Peroxisome proliferator activated receptor-gamma (PPAR-gamma) agonists thiazolidinediones (TZDs) are thought to ameliorate hyperandrogenism in polycystic ovary syndrome by reducing hyperinsulinemia. However, TZDs also exhibit direct effects in the human ovary. We examined interactions among PPAR-gamma, insulin signaling pathways, and steroidogenic acute regulatory (StAR) protein in human ovarian cells.

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