Adult Hypophosphatasia Treated with Teriparatide | Zendy

Michael P. Whyte | Zendy; Steven Mumm | Zendy; Chad Deal | Zendy

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Adult Hypophosphatasia Treated with Teriparatide

Author(s) -

Michael P. Whyte,

Steven Mumm,

Chad Deal

Publication year - 2007

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2006-1902

Subject(s) - hypophosphatasia , teriparatide , medicine , pediatrics , chemistry , alkaline phosphatase , osteoporosis , biochemistry , enzyme , bone mineral

Hypophosphatasia (HPP) features low serum alkaline phosphatase (ALP) activity (hypophosphatasemia) due to loss-of-function mutation within TNSALP, the gene that encodes "tissue-nonspecific" ALP (TNSALP). Consequently, inorganic pyrophosphate accumulates extracellularly and impairs skeletal mineralization. Affected adults manifest osteomalacia, often with slowly healing metatarsal stress fractures (MTSFs) and proximal femur pseudofractures. Pharmacotherapy remains elusive.

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