The Circadian Rhythm of Osteoprotegerin and Its Association with Parathyroid Hormone Secretion | Zendy

Franklin Joseph | Zendy; Belinda Chan | Zendy; Benjamin H. Durham | Zendy; Aftab Ahmad | Zendy; Sobhan Vinjamuri | Zendy; J.A. Gallagher | Zendy; Jiten Vora | Zendy; William D. Fraser | Zendy

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The Circadian Rhythm of Osteoprotegerin and Its Association with Parathyroid Hormone Secretion

Author(s) -

Franklin Joseph,

Belinda Chan,

Benjamin H. Durham,

Aftab Ahmad,

Sobhan Vinjamuri,

J.A. Gallagher,

Jiten Vora,

William D. Fraser

Publication year - 2007

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2006-1832

Subject(s) - medicine , endocrinology , circadian rhythm , osteoprotegerin , parathyroid hormone , bone remodeling , menopause , n terminal telopeptide , hormone , calcium , chemistry , receptor , osteocalcin , alkaline phosphatase , biochemistry , enzyme , activator (genetics)

Osteoclast resorptive activity, which is known to demonstrate circadian rhythmicity, is regulated by various endocrine hormones and cytokines. PTH suppresses osteoprotegerin (OPG), a regulator of osteoclast activity that has recently been shown to have a circadian rhythm in healthy controls. We studied the differences in the relationship between PTH, OPG, and type I collagen C-telopeptide (betaCTX) over a 24-h period in premenopausal women, elderly postmenopausal women, and elderly men.

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