Relationship of the Human Growth Hormone Receptor Exon 3 Genotype with Final Adult Height and Bone Mineral Density | Zendy

Gurvinder Kenth | Zendy; Zhuo Shao | Zendy; David E.C. Cole | Zendy; Cynthia G. Goodyer | Zendy

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Relationship of the Human Growth Hormone Receptor Exon 3 Genotype with Final Adult Height and Bone Mineral Density

Author(s) -

Gurvinder Kenth,

Zhuo Shao,

David E.C. Cole,

Cynthia G. Goodyer

Publication year - 2006

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2006-1695

Subject(s) - medicine , bone mineral , femoral neck , cohort , growth hormone receptor , exon , population , genotype , osteoporosis , genetics , biology , growth hormone , hormone , gene , environmental health

Three recent clinical studies have reported that two of the most common isoforms of the human GH (hGH) receptor (hGHR), exon 3 full-length (3+) and exon 3 deleted (3-), may have differential effects on the growth response of children receiving hGH therapy, whereas others refute this. However, none of the investigations has explored the relationship between these hGHR isoforms and final adult height (FAH) or measures of bone mineral density (BMD) within a healthy adult population.

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