Association of Acylated and Nonacylated Ghrelin with Insulin Sensitivity in Overweight and Obese Postmenopausal Women | Zendy

David H. StPierre | Zendy; Antony D. Karelis | Zendy; Lise Coderre | Zendy; F.M. Malita | Zendy; Jonathan Fontaine | Zendy; Diane Mignault | Zendy; Martin Brochu | Zendy; JeanPhilippe Bastard | Zendy; Katherine Cianflone | Zendy; Éric Doucet | Zendy; Pascal Imbeault | Zendy; Rémi RabasaLhoret | Zendy

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Association of Acylated and Nonacylated Ghrelin with Insulin Sensitivity in Overweight and Obese Postmenopausal Women

Author(s) -

David H. StPierre,

Antony D. Karelis,

Lise Coderre,

F.M. Malita,

Jonathan Fontaine,

Diane Mignault,

Martin Brochu,

JeanPhilippe Bastard,

Katherine Cianflone,

Éric Doucet,

Pascal Imbeault,

Rémi RabasaLhoret

Publication year - 2006

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2006-1603

Subject(s) - medicine , endocrinology , overweight , ghrelin , insulin , insulin resistance , obesity , insulin sensitivity , pancreatic hormone , glucose clamp technique , hormone

Ghrelin [acylated (AG) and nonacylated (NAG)] has been shown to play a pivotal role in the regulation of food intake and insulin sensitivity. It is presently unclear whether variation in insulin sensitivity is related to AG and NAG levels in obese individuals. To address this issue, we determined whether insulin-sensitive overweight or obese (ISO) and insulin-resistant overweight or obese (IRO) individuals display different total ghrelin (TotG), AG, and NAG profiles during a euglycemic/hyperinsulinemic clamp (EHC).

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