The Impact of Estradiol on Bone Mineral Density Is Modulated by the Specific Estrogen Receptor-α Cofactor Retinoblastoma-Interacting Zinc Finger Protein-1 Insertion/Deletion Polymorphism | Zendy

Elin Grundberg | Zendy; Kristina Åkesson | Zendy; Andreas Kindmark | Zendy; Paul Gerdhem | Zendy; Anna Holmberg | Zendy; Dan Mellström | Zendy; Östen Ljunggren | Zendy; Eric Orwoll | Zendy; Hans Mallmin | Zendy; Claes Ohlsson | Zendy; Helena Brändström | Zendy

Open Access

The Impact of Estradiol on Bone Mineral Density Is Modulated by the Specific Estrogen Receptor-α Cofactor Retinoblastoma-Interacting Zinc Finger Protein-1 Insertion/Deletion Polymorphism

Author(s) -

Elin Grundberg,

Kristina Åkesson,

Andreas Kindmark,

Paul Gerdhem,

Anna Holmberg,

Dan Mellström,

Östen Ljunggren,

Eric Orwoll,

Hans Mallmin,

Claes Ohlsson,

Helena Brändström

Publication year - 2007

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2006-1572

Subject(s) - bone mineral , femoral neck , medicine , endocrinology , estrogen receptor , bone density , estrogen , genotype , osteoporosis , zinc finger , estrogen receptor alpha , biology , genetics , gene , breast cancer , cancer , transcription factor

Estrogens regulate bone mass by binding to the estrogen receptor (ER)-alpha as well as ER-beta. The specific ERalpha cofactor retinoblastoma-interacting zinc finger protein (RIZ)-1 enhances ERalpha function in the presence of estrogen.

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