Impaired Caspase-3 Expression by Peripheral T Cells in Chronic Autoimmune Thyroiditis and in Autoimmune Polyendocrine Syndrome-2 | Zendy

Francesco Vendrame | Zendy; Maria Segni | Zendy; D. Grassetti | Zendy; Valeria Tellone | Zendy; Giovanni Augello | Zendy; Vincenzo Trischitta | Zendy; Massimo Torlontano | Zendy; Francesco Dotta | Zendy

Open Access

Impaired Caspase-3 Expression by Peripheral T Cells in Chronic Autoimmune Thyroiditis and in Autoimmune Polyendocrine Syndrome-2

Author(s) -

Francesco Vendrame,

Maria Segni,

D. Grassetti,

Valeria Tellone,

Giovanni Augello,

Vincenzo Trischitta,

Massimo Torlontano,

Francesco Dotta

Publication year - 2006

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2006-1358

Subject(s) - autoimmune thyroiditis , medicine , autoimmunity , endocrinology , thyroiditis , peripheral blood mononuclear cell , autoimmune disease , caspase 3 , immunology , western blot , thyroid , apoptosis , biology , antibody , programmed cell death , gene , in vitro , biochemistry

Activation-induced cell death (AICD) is a major mechanism in the regulation of peripheral tolerance, and caspase-3 represents its major executioner. AICD impairment contributes to the persistence of autoreactive T cells, and defective AICD has been reported in autoimmune thyroiditis as well as in type 1 diabetes mellitus.

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