Lack of Association of the 11β-Hydroxysteroid Dehydrogenase Type 1 Gene 83,557insA and Hexose-6-Phosphate Dehydrogenase Gene R453Q Polymorphisms with Body Composition, Adrenal Androgen Production, Blood Pressure, Glucose Metabolism, and Dementia | Zendy

Pauline Smit | Zendy; Marieke J. H. J. Dekker | Zendy; Frank Jan de Jong | Zendy; Annewieke W. van den Beld | Zendy; Jan W. Koper | Zendy; Huibert A. P. Pols | Zendy; Albert O. Brinkmann | Zendy; Frank H. de Jong | Zendy; Monique M.B. Breteler | Zendy; Steven W. J. Lamberts | Zendy

Open Access

Lack of Association of the 11β-Hydroxysteroid Dehydrogenase Type 1 Gene 83,557insA and Hexose-6-Phosphate Dehydrogenase Gene R453Q Polymorphisms with Body Composition, Adrenal Androgen Production, Blood Pressure, Glucose Metabolism, and Dementia

Author(s) -

Pauline Smit,

Marieke J. H. J. Dekker,

Frank Jan de Jong,

Annewieke W. van den Beld,

Jan W. Koper,

Huibert A. P. Pols,

Albert O. Brinkmann,

Frank H. de Jong,

Monique M.B. Breteler,

Steven W. J. Lamberts

Publication year - 2006

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2006-1349

Subject(s) - dehydrogenase , allele , gene , 11β hydroxysteroid dehydrogenase type 1 , endocrinology , cortisone , biology , medicine , biochemistry , enzyme

Recently, it was proposed that a combination of the 83,557insA polymorphism in the 11beta-hydroxysteroid dehydrogenase type 1 (HSD11B1) gene and the R453Q polymorphism in the hexose-6-phosphate dehydrogenase (H6PD) gene interacts to cause cortisone reductase deficiency (CRD) when at least three alleles are affected.

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