Adipose Triglyceride Lipase and Hormone-Sensitive Lipase Protein Expression Is Decreased in the Obese Insulin-Resistant State | Zendy

Johan W. E. Jocken | Zendy; Dominique Langin | Zendy; Egbert F. Smit | Zendy; Wim H. M. Saris | Zendy; Carine Valle | Zendy; Gabby B. Hul | Zendy; Cecilia Holm | Zendy; Peter Arner | Zendy; Ellen E. Blaak | Zendy

Open Access

Adipose Triglyceride Lipase and Hormone-Sensitive Lipase Protein Expression Is Decreased in the Obese Insulin-Resistant State

Author(s) -

Johan W. E. Jocken,

Dominique Langin,

Egbert F. Smit,

Wim H. M. Saris,

Carine Valle,

Gabby B. Hul,

Cecilia Holm,

Peter Arner,

Ellen E. Blaak

Publication year - 2007

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2006-1318

Subject(s) - adipose triglyceride lipase , hormone sensitive lipase , medicine , insulin resistance , endocrinology , adipose tissue , insulin , hyperinsulinemia , triglyceride , white adipose tissue , lipase , biology , chemistry , cholesterol , lipolysis , enzyme , biochemistry

Obesity is associated with increased triacylglycerol (TAG) storage in adipose tissue and insulin resistance. The mobilization of stored TAG is mediated by hormone-sensitive lipase (HSL) and the recently discovered adipose triglyceride lipase (ATGL). The aim of the present study was to examine whether ATGL and HSL mRNA and protein expression are altered in insulin-resistant conditions. In addition, we investigated whether a possible impaired expression could be reversed by a period of weight reduction.

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