Cis-Unsaturated Fatty Acids Stimulate Reactive Oxygen Species Generation and Lipid Peroxidation in Human Spermatozoa | Zendy

R. John Aitken | Zendy; Jordana K. Wingate | Zendy; Geoffry N. De Iuliis | Zendy; Adam J. Koppers | Zendy; Eileen A. McLaughlin | Zendy

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Cis-Unsaturated Fatty Acids Stimulate Reactive Oxygen Species Generation and Lipid Peroxidation in Human Spermatozoa

Author(s) -

R. John Aitken,

Jordana K. Wingate,

Geoffry N. De Iuliis,

Adam J. Koppers,

Eileen A. McLaughlin

Publication year - 2006

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2006-1309

Subject(s) - reactive oxygen species , oxidative stress , context (archaeology) , lipid peroxidation , semen , infertility , sperm , biology , biochemistry , etiology , andrology , chemistry , medicine , anatomy , genetics , pregnancy , paleontology

Defective sperm function is the largest defined cause of human infertility; however, the etiology of this condition is poorly understood. Although oxidative stress is acknowledged as a key contributor to this pathology, there are also data indicating that defective human spermatozoa contain abnormally high amounts of cis-unsaturated fatty acids. This study investigated whether a causative relationship exists between these two attributes of impaired semen quality.

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