MHC2TA Single Nucleotide Polymorphism and Genetic Risk for Autoimmune Adrenal Insufficiency | Zendy

Mehran Ghaderi | Zendy; Giovanni Gambelunghe | Zendy; Cristina Tortoioli | Zendy; Annalisa Brozzetti | Zendy; Kenbugul Jatta | Zendy; Baback Gharizadeh | Zendy; Annamaria De Bellis | Zendy; Francesca Pecori Giraldi | Zendy; Massimo Terzolo | Zendy; Corrado Betterle | Zendy; Alberto Falorni | Zendy

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MHC2TA Single Nucleotide Polymorphism and Genetic Risk for Autoimmune Adrenal Insufficiency

Author(s) -

Mehran Ghaderi,

Giovanni Gambelunghe,

Cristina Tortoioli,

Annalisa Brozzetti,

Kenbugul Jatta,

Baback Gharizadeh,

Annamaria De Bellis,

Francesca Pecori Giraldi,

Massimo Terzolo,

Corrado Betterle,

Alberto Falorni

Publication year - 2006

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2006-0855

Subject(s) - adrenal insufficiency , single nucleotide polymorphism , genetics , polymorphism (computer science) , medicine , biology , immunology , genotype , gene

The polymorphism of class II HLA genes modulates the genetic risk for several endocrine autoimmune diseases. The constitutive class II expression on antigen-presenting cells is under the control of the MHC class II transactivator, encoded by the MHC2TA gene, which is mapped to chromosome 16p13. The MHC2TA -168 A-->G single nucleotide polymorphism (rs3087456) has been suggested to confer susceptibility to some autoimmune diseases.

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