Acute In Vivo Regulation of 11β-Hydroxysteroid Dehydrogenase Type 1 Activity by Insulin and Intralipid Infusions in Humans | Zendy

Deborah J. Wake | Zendy; Natalie Homer | Zendy; Ruth Andrew | Zendy; Brian R. Walker | Zendy

Open Access

Acute In Vivo Regulation of 11β-Hydroxysteroid Dehydrogenase Type 1 Activity by Insulin and Intralipid Infusions in Humans

Author(s) -

Deborah J. Wake,

Natalie Homer,

Ruth Andrew,

Brian R. Walker

Publication year - 2006

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2006-0819

Subject(s) - in vivo , insulin , medicine , dehydrogenase , endocrinology , chemistry , biology , enzyme , biochemistry , microbiology and biotechnology

Extraadrenal regeneration of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 (11HSD1) is increased after a mixed meal. It is unknown which tissue is responsible and whether this reflects the complex transcriptional control of 11HSD1 or posttranscriptional control exerted by supply of reduced nicotinamide adenine dinucleotide phosphate from hexose-6-phosphate dehydrogenase.

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