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SHBG Gene Promoter Polymorphisms in Men Are Associated with Serum Sex Hormone-Binding Globulin, Androgen and Androgen Metabolite Levels, and Hip Bone Mineral Density
Author(s) -
Anna L. Eriksson,
Mattias Lorentzon,
Dan Mellström,
Liesbeth Vandenput,
Charlotte Swanson,
Niklas Andersson,
Geoffrey L. Hammond,
Jenny Jakobsson,
Anders Rane,
Eric Orwoll,
Östen Ljunggren,
O. Johnell,
Fernand Labrie,
Sara H. Windahl,
Claes Ohlsson
Publication year - 2006
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2006-0679
Subject(s) - sex hormone binding globulin , endocrinology , medicine , androgen , dihydrotestosterone , bone mineral , testosterone (patch) , osteoporosis , biology , hormone
SHBG regulates free sex steroid levels, which in turn regulate skeletal homeostasis. Twin studies have demonstrated that genetic factors largely account for interindividual variation in SHBG levels. Glucuronidated androgen metabolites have been proposed as markers of androgenic activity.

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