Free/Dissociable Insulin-Like Growth Factor (IGF)-I, Not Total IGF-I, Correlates with Growth Response during Growth Hormone Treatment in Children Born Small for Gestational Age | Zendy

Ellen M.N. Bannink | Zendy; Jaap van Doorn | Zendy; Paul Mulder | Zendy; Anita Hokken-Koelega | Zendy

Open Access

Free/Dissociable Insulin-Like Growth Factor (IGF)-I, Not Total IGF-I, Correlates with Growth Response during Growth Hormone Treatment in Children Born Small for Gestational Age

Author(s) -

Ellen M.N. Bannink,

Jaap van Doorn,

Paul Mulder,

Anita Hokken-Koelega

Publication year - 2007

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2006-0677

Subject(s) - medicine , endocrinology , discontinuation , context (archaeology) , small for gestational age , growth hormone treatment , insulin like growth factor , growth factor , growth hormone , gestational age , hormone , pregnancy , biology , receptor , genetics , paleontology

IGF-I plays an important role in pre- and postnatal growth. Its serum levels are regulated by metabolic and genetic factors. Mean total IGF-I in short, small for gestational age (SGA) children is reduced, but within the normal range. Free/dissociable IGF-I is the bioactive form of IGF-I.

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