The Suppressor of Cytokine Signaling 3 Inhibits Leptin Activation of AMP-Kinase in Cultured Skeletal Muscle of Obese Humans | Zendy

Gregory R. Steinberg | Zendy; Andrew J. McAinch | Zendy; Michael B. Chen | Zendy; Paul E. O’Brien | Zendy; John B. Dixon | Zendy; David CameronSmith | Zendy; Bruce E. Kemp | Zendy

Open Access

The Suppressor of Cytokine Signaling 3 Inhibits Leptin Activation of AMP-Kinase in Cultured Skeletal Muscle of Obese Humans

Author(s) -

Gregory R. Steinberg,

Andrew J. McAinch,

Michael B. Chen,

Paul E. O’Brien,

John B. Dixon,

David CameronSmith,

Bruce E. Kemp

Publication year - 2006

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2006-0638

Subject(s) - socs3 , endocrinology , ampk , medicine , leptin , amp activated protein kinase , myogenesis , skeletal muscle , beta oxidation , protein kinase a , chemistry , signal transduction , biology , phosphorylation , metabolism , biochemistry , stat3 , obesity

Leptin is thought to regulate whole-body adiposity and insulin sensitivity, at least in part, by stimulating fatty acid metabolism via activation of AMP-kinase (AMPK) in skeletal muscle. Human obesity is associated with leptin resistance, and recent studies have demonstrated that hypothalamic expression of the suppressors of cytokine signaling 3 (SOCS3) regulates leptin sensitivity in rodents.

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