ENPP1 Variants and Haplotypes Predispose to Early Onset Obesity and Impaired Glucose and Insulin Metabolism in German Obese Children | Zendy

Yvonne Böttcher | Zendy; Antje Körner | Zendy; Thomas Reinehr | Zendy; Beate Enigk | Zendy; Wieland Kieß | Zendy; Michael Stümvoll | Zendy; Péter Kovács | Zendy

Open Access

ENPP1 Variants and Haplotypes Predispose to Early Onset Obesity and Impaired Glucose and Insulin Metabolism in German Obese Children

Author(s) -

Yvonne Böttcher,

Antje Körner,

Thomas Reinehr,

Beate Enigk,

Wieland Kieß,

Michael Stümvoll,

Péter Kovács

Publication year - 2006

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2006-0540

Subject(s) - insulin resistance , medicine , endocrinology , obesity , overweight , haplotype , body mass index , context (archaeology) , insulin , population , odds ratio , carbohydrate metabolism , biology , genetics , genotype , gene , paleontology , environmental health

ENPP1 (nucleotide pyrophosphatase/phosphodiesterase-1) encodes a membrane-bound glycoprotein that inhibits the insulin-receptor tyrosine kinase activity, resulting in reduced insulin sensitivity. Hence, variants in this gene may be related to obesity and insulin resistance.

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