Open AccessRET/Papillary Thyroid Cancer Rearrangement in Nonneoplastic Thyrocytes: Follicular Cells of Hashimoto’s Thyroiditis Share Low-Level Recombination Events with a Subset of Papillary Carcinoma
Author(s) -
Kerry J. Rhoden,
Kristian Unger,
Giuliana Salvatore,
Yesim Yilmaz,
Volodymyr Vovk,
Gennaro Chiappetta,
Mazin B. Qumsiyeh,
Jay L. Rothstein,
Alfredo Fusco,
Massimo Santoro,
Horst Zitzelsberger,
Giovanni Tallini
Publication year - 2006
Publication title -
the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2006-0240
Subject(s) - thyroiditis , thyroid carcinoma , fluorescence in situ hybridization , pathology , laser capture microdissection , thyroid , medicine , thyroid cancer , papillary thyroid cancer , microdissection , follicular phase , cancer research , endocrinology , biology , gene expression , gene , biochemistry , chromosome
RET/papillary thyroid cancer (PTC) is a marker for papillary thyroid carcinoma, but its specificity has been questioned because of the disputed identification of RET/PTC in Hashimoto's thyroiditis (HT), oncocytic tumors, and other thyroid lesions.