Neonatal Screening for Congenital Hypothyroidism Based on Thyroxine, Thyrotropin, and Thyroxine-Binding Globulin Measurement: Potentials and Pitfalls | Zendy

Marlies Kempers | Zendy; C.I. Lanting | Zendy; Arno van Heijst | Zendy; A.S. Paul van Trotsenburg | Zendy; Brenda M. Wiedijk | Zendy; Jan J. M. de Vijlder | Zendy; T. Vulsma | Zendy

Open Access

Neonatal Screening for Congenital Hypothyroidism Based on Thyroxine, Thyrotropin, and Thyroxine-Binding Globulin Measurement: Potentials and Pitfalls

Author(s) -

Marlies Kempers,

C.I. Lanting,

Arno van Heijst,

A.S. Paul van Trotsenburg,

Brenda M. Wiedijk,

Jan J. M. de Vijlder,

T. Vulsma

Publication year - 2006

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2006-0058

Subject(s) - thyroxine binding globulin , congenital hypothyroidism , endocrinology , medicine , thyrotropin receptor , thyroid , triiodothyronine , graves' disease

The Dutch T(4)-TSH-TBG-based neonatal screening program detects patients with congenital hypothyroidism (CH) of thyroidal (CH-T) as well as central (CH-C) origin. The numbers and characteristics of true-positive and false-positive referrals will differ from other, predominantly TSH-based, screening methods.

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