Effects of Insulin Deprivation and Treatment on Homocysteine Metabolism in People with Type 1 Diabetes | Zendy

Haitham S. Abu-Lebdeh | Zendy; Rocco Barazzoni | Zendy; Shon Meek | Zendy; Maureen L. Bigelow | Zendy; Xuan-Mai T. Persson | Zendy; K. Sreekumaran Nair | Zendy

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Effects of Insulin Deprivation and Treatment on Homocysteine Metabolism in People with Type 1 Diabetes

Author(s) -

Haitham S. Abu-Lebdeh,

Rocco Barazzoni,

Shon Meek,

Maureen L. Bigelow,

Xuan-Mai T. Persson,

K. Sreekumaran Nair

Publication year - 2006

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2006-0018

Subject(s) - transsulfuration , homocysteine , endocrinology , medicine , insulin , transmethylation , methionine , metabolism , cystathionine beta synthase , chemistry , biology , biochemistry , amino acid

Abnormal homocysteine metabolism may contribute to increased cardiovascular death in type 1 diabetes (T1DM). Amino acid metabolism is altered in T1DM. In vitro, insulin reduces hepatic catabolism of homocysteine by inhibiting liver transsulfuration. It remains to be determined whether methionine-homocysteine metabolism is altered in T1DM.

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