Effects of Selective Testosterone and Estradiol Withdrawal on Skeletal Sensitivity to Parathyroid Hormone in Men | Zendy

Hang Lee | Zendy; Joel S. Finkelstein | Zendy; Megan E. Miller | Zendy; Sarah J. Comeaux | Zendy; Rachel Cohen | Zendy; Benjamin Z. Leder | Zendy

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Effects of Selective Testosterone and Estradiol Withdrawal on Skeletal Sensitivity to Parathyroid Hormone in Men

Author(s) -

Hang Lee,

Joel S. Finkelstein,

Megan E. Miller,

Sarah J. Comeaux,

Rachel Cohen,

Benjamin Z. Leder

Publication year - 2006

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2005-2495

Subject(s) - testosterone (patch) , medicine , endocrinology , parathyroid hormone , hormone , calcium

Gonadal steroid withdrawal increases bone turnover and causes bone loss in men, but the underlying mechanisms have not been defined. We previously reported that gonadal steroid deprivation increases the skeletal sensitivity to the bone resorbing properties of PTH infusion in men, but it is not known whether this effect is mediated by the absence of androgens, estrogens, or both.

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