Bone Turnover across the Menopause Transition: Correlations with Inhibins and Follicle-Stimulating Hormone | Zendy

Daniel S. Perrien | Zendy; Sara J. Achenbach | Zendy; Samuel E. Bledsoe | Zendy; Brandon Walser | Zendy; Larry J. Suva | Zendy; Sundeep Khosla | Zendy; Dana Gaddy | Zendy

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Bone Turnover across the Menopause Transition: Correlations with Inhibins and Follicle-Stimulating Hormone

Author(s) -

Daniel S. Perrien,

Sara J. Achenbach,

Samuel E. Bledsoe,

Brandon Walser,

Larry J. Suva,

Sundeep Khosla,

Dana Gaddy

Publication year - 2006

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2005-2423

Subject(s) - osteoclast , medicine , bone remodeling , endocrinology , context (archaeology) , follicle stimulating hormone , osteoblast , menopause , hormone , chemistry , biology , luteinizing hormone , receptor , in vitro , biochemistry , paleontology

Longitudinal clinical studies demonstrate that increases in bone turnover that occur in perimenopausal women correlate better with elevated serum FSH than with changes in serum estradiol (E2). This perimenopausal rise in FSH is due to a selective decrease in ovarian inhibin B (InhB). Our previous demonstration that inhibins suppress both osteoblast and osteoclast development suggests that changes in serum inhibins may regulate osteoblast and osteoclast differentiation and thereby bone turnover, independent of changes in sex steroids.

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