Leptin Interferes with Adrenocorticotropin/3′,5′-Cyclic Adenosine Monophosphate (cAMP) Signaling, Possibly through a Janus Kinase 2-Phosphatidylinositol 3-Kinase/Akt-Phosphodiesterase 3-cAMP Pathway, to Down-Regulate Cholesterol Side-Chain Cleavage Cytochrome P450 Enzyme in Human Adrenocortical NCI-H295 Cell Line | Zendy

Haoting Hsu | Zendy; YuanChing Chang | Zendy; Yi-Ning Chiu | Zendy; ChienLiang Liu | Zendy; KingJen Chang | Zendy; Ing-Cherng Guo | Zendy

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Leptin Interferes with Adrenocorticotropin/3′,5′-Cyclic Adenosine Monophosphate (cAMP) Signaling, Possibly through a Janus Kinase 2-Phosphatidylinositol 3-Kinase/Akt-Phosphodiesterase 3-cAMP Pathway, to Down-Regulate Cholesterol Side-Chain Cleavage Cytochrome P450 Enzyme in Human Adrenocortical NCI-H295 Cell Line

Author(s) -

Haoting Hsu,

YuanChing Chang,

Yi-Ning Chiu,

ChienLiang Liu,

KingJen Chang,

Ing-Cherng Guo

Publication year - 2006

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2005-2383

Subject(s) - endocrinology , medicine , leptin , cholera toxin , protein kinase b , steroidogenic acute regulatory protein , cholesterol side chain cleavage enzyme , leptin receptor , biology , protein kinase a , chemistry , signal transduction , kinase , biochemistry , gene expression , cytochrome p450 , metabolism , gene , obesity

Obesity has adverse effects on adrenocortical functions. Adipocyte-derived leptin, a biomarker molecule of obesity, may directly control adrenal steroidogenesis via an unclear mechanism.

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