Genetic Variation in 11β-Hydroxysteroid Dehydrogenase Type 1 Predicts Adrenal Hyperandrogenism among Lean Women with Polycystic Ovary Syndrome | Zendy

Alessandra Gambineri | Zendy; Valentina Vicennati | Zendy; Silvia Genghini | Zendy; Federica Tomassoni | Zendy; Uberto Pagotto | Zendy; Renato Pasquali | Zendy; Brian R. Walker | Zendy

Open Access

Genetic Variation in 11β-Hydroxysteroid Dehydrogenase Type 1 Predicts Adrenal Hyperandrogenism among Lean Women with Polycystic Ovary Syndrome

Author(s) -

Alessandra Gambineri,

Valentina Vicennati,

Silvia Genghini,

Federica Tomassoni,

Uberto Pagotto,

Renato Pasquali,

Brian R. Walker

Publication year - 2006

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2005-2222

Subject(s) - endocrinology , medicine , polycystic ovary , hyperandrogenism , dehydroepiandrosterone sulfate , androgen , obesity , dehydroepiandrosterone , cortisone , context (archaeology) , glucocorticoid , biology , hormone , insulin resistance , paleontology

Elevated adrenal androgen levels are common in polycystic ovary syndrome (PCOS), but the underlying pathogenetic mechanism is poorly understood. In the rare cortisone reductase deficiency, impaired regeneration of active cortisol from inert cortisone by 11beta-hydroxysteroid dehydrogenase (11beta-HSD1) results in compensatory activation of ACTH secretion and adrenal hyperandrogenism. 11beta-HSD1 deficiency may protect against obesity and its metabolic consequences because of impaired regeneration of cortisol in adipose tissue.

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