Estrogen-Mediated Regulation of p38 Mitogen-Activated Protein Kinase in Human Endometrium | Zendy

Yasemin Seval | Zendy; Hakan Çakmak | Zendy; Umit A. Kayisli | Zendy; Aydın Arıcı | Zendy

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Estrogen-Mediated Regulation of p38 Mitogen-Activated Protein Kinase in Human Endometrium

Author(s) -

Yasemin Seval,

Hakan Çakmak,

Umit A. Kayisli,

Aydın Arıcı

Publication year - 2006

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2005-2132

Subject(s) - estrogen , p38 mitogen activated protein kinases , mapk/erk pathway , estrogen receptor , microbiology and biotechnology , protein kinase a , biology , estrogen receptor beta , mitogen activated protein kinase , transcription factor , mediator , signal transduction , endometrium , cancer research , kinase , endocrinology , gene , genetics , cancer , breast cancer

Estrogen predominantly exerts its biological effects through the genomic pathway by binding to its intracellular receptors, interacting with the estrogen response element located in the promoter region of the target gene, and thus regulating gene transcription. There has been an increasing body of evidence regarding nongenomic actions of estrogen. Estrogen activates multiple signaling cascades, including the MAPK pathway. p38 MAPK plays key roles in mediating apoptosis, proliferation, and inflammation, which all take place in the endometrium during cyclical changes under the influence of estrogen.

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