Pituitary Tumor-Transforming Gene Regulates Multiple Downstream Angiogenic Genes in Thyroid Cancer | Zendy

D. S. Kim | Zendy; J. A. Franklyn | Zendy; Anna L. Stratford | Zendy; Kristien Boelaert | Zendy; John Watkinson | Zendy; Margaret C. Eggo | Zendy; Christopher J. McCabe | Zendy

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Pituitary Tumor-Transforming Gene Regulates Multiple Downstream Angiogenic Genes in Thyroid Cancer

Author(s) -

D. S. Kim,

J. A. Franklyn,

Anna L. Stratford,

Kristien Boelaert,

John Watkinson,

Margaret C. Eggo,

Christopher J. McCabe

Publication year - 2006

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2005-1826

Subject(s) - angiogenesis , cancer research , thyroid cancer , thyroid , biology , follicular thyroid cancer , papillary thyroid cancer , medicine , endocrinology

Pituitary tumor-transforming gene (PTTG) is a multifunctional protein involved in several tumorigenic mechanisms, including angiogenesis. PTTG has been shown to promote angiogenesis, a key rate-limiting step in tumor progression, by up-regulation of fibroblast growth factor-2 and vascular endothelial growth factor.

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