Thrombin and Interleukin-1β Regulate HOXA10 Expression in Human Term Decidual Cells: Implications for Preterm Labor | Zendy

Jennifer Sarno | Zendy; Frederick Schatz | Zendy; Charles J. Lockwood | Zendy; S.T. Joseph Huang | Zendy; Hugh S. Taylor | Zendy

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Thrombin and Interleukin-1β Regulate HOXA10 Expression in Human Term Decidual Cells: Implications for Preterm Labor

Author(s) -

Jennifer Sarno,

Frederick Schatz,

Charles J. Lockwood,

S.T. Joseph Huang,

Hugh S. Taylor

Publication year - 2006

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2005-1807

Subject(s) - decidua , thrombin , decidual cells , context (archaeology) , decidualization , proinflammatory cytokine , medicine , andrology , interleukin 8 , stromal cell , endocrinology , chemistry , biology , placenta , inflammation , pregnancy , fetus , platelet , paleontology , genetics

Preterm delivery is commonly caused by intraamniotic infection with expression of proinflammatory cytokines (IL-1beta) or by abruption resulting in generation of decidual thrombin. Although human parturition is not preceded by overt progesterone withdrawal, progesterone resistance likely leads to labor. The uteri of Hoxa10(-/-) mice demonstrate progesterone resistance; several genes, including prostaglandin receptors, are inappropriately regulated in response to progesterone.

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