Large Differences in Testosterone Excretion in Korean and Swedish Men Are Strongly Associated with a UDP-Glucuronosyl Transferase 2B17 Polymorphism | Zendy

Jenny Jakobsson | Zendy; Lena Ekström | Zendy; Nobuo Inotsume | Zendy; Mats Garle | Zendy; Mattias Lorentzon | Zendy; Claes Ohlsson | Zendy; HyungKeun Roh | Zendy; Kjell Carlström | Zendy; Anders Rane | Zendy

Open Access

Large Differences in Testosterone Excretion in Korean and Swedish Men Are Strongly Associated with a UDP-Glucuronosyl Transferase 2B17 Polymorphism

Author(s) -

Jenny Jakobsson,

Lena Ekström,

Nobuo Inotsume,

Mats Garle,

Mattias Lorentzon,

Claes Ohlsson,

HyungKeun Roh,

Kjell Carlström,

Anders Rane

Publication year - 2006

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2005-1643

Subject(s) - testosterone (patch) , excretion , medicine , transferase , endocrinology , psychology , biology , enzyme , biochemistry

The reproductive endocrinology in Asians and Caucasians is of great interest in view of large differences in prostate cancer rate and sensitivity to pharmacological male contraception. In addition, interpretation of certain antidoping tests is confounded by interethnic variation in androgen disposition. Uridine diphosphoglucuronosyl transferases have a key role in the homeostasis and metabolism of androgens. Recently a deletion polymorphism was detected in the UGT2B17 gene.

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