The Role of CBP/p300 Interactions and Pit-1 Dimerization in the Pathophysiological Mechanism of Combined Pituitary Hormone Deficiency | Zendy

Ronald N. Cohen | Zendy; Thierry Brue | Zendy; Karuik | Zendy; Christine Houlihan | Zendy; Fredric E. Wondisford | Zendy; S. Radovick | Zendy

Open Access

The Role of CBP/p300 Interactions and Pit-1 Dimerization in the Pathophysiological Mechanism of Combined Pituitary Hormone Deficiency

Author(s) -

Ronald N. Cohen,

Thierry Brue,

Karuik,

Christine Houlihan,

Fredric E. Wondisford,

S. Radovick

Publication year - 2006

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2005-1211

Subject(s) - mechanism (biology) , pathophysiology , pituitary hormones , neuroscience , hormone , chemistry , endocrinology , medicine , biology , physics , quantum mechanics

Combined pituitary hormone deficiency (CPHD) in humans is caused by mutations of pituitary-specific transcription factors such as Pit-1. Although many patients with CPHD have an autosomal recessive disorder caused by a Pit-1 DNA-binding mutation, there are a number of reports of mutant Pit-1 molecules that either by prediction or through experimentation bind normally to DNA.

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