Genetic Variation in the Hypoxia-Inducible Factor-1α Gene Is Associated with Type 2 Diabetes in Japanese | Zendy

Norihiro Yamada | Zendy; Yukio Horikawa | Zendy; Naohisa Oda | Zendy; Katsumi Iizuka | Zendy; Nobuyuki Shihara | Zendy; Shoji Kishi | Zendy; Jun Takeda | Zendy

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Genetic Variation in the Hypoxia-Inducible Factor-1α Gene Is Associated with Type 2 Diabetes in Japanese

Author(s) -

Norihiro Yamada,

Yukio Horikawa,

Naohisa Oda,

Katsumi Iizuka,

Nobuyuki Shihara,

Shoji Kishi,

Jun Takeda

Publication year - 2005

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2005-0991

Subject(s) - single nucleotide polymorphism , biology , vascular endothelial growth factor , type 2 diabetes , haplotype , endocrinology , diabetic retinopathy , linkage disequilibrium , medicine , exon , hypoxia inducible factors , neovascularization , diabetes mellitus , angiogenesis , genetics , gene , cancer research , genotype , vegf receptors

Vascular endothelial growth factor plays a critical role both in neovascularization of proliferative diabetic retinopathy and in angiogenesis of islets in the pancreatic developmental stage in determining beta-cell mass and properties. Vascular endothelial growth factor mRNA levels increase as a result of increased transcriptional activation, mediated predominantly by hypoxia-inducible factor-1 alpha (HIF-1alpha) in response to hypoxia.

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