An Ovulatory Gonadotropin Stimulus Increases Cytosolic Phospholipase A2 Expression and Activity in Granulosa Cells of Primate Periovulatory Follicles | Zendy

Diane M. Duffy | Zendy; Carrie L. Seachord | Zendy; Brandy L. Dozier | Zendy

Open Access

An Ovulatory Gonadotropin Stimulus Increases Cytosolic Phospholipase A2 Expression and Activity in Granulosa Cells of Primate Periovulatory Follicles

Author(s) -

Diane M. Duffy,

Carrie L. Seachord,

Brandy L. Dozier

Publication year - 2005

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2005-0980

Subject(s) - endocrinology , medicine , gonadotropin , human chorionic gonadotropin , follicular phase , biology , ovarian follicle , granulosa cell , phospholipase a2 , arachidonic acid , ovulation , equine chorionic gonadotropin , hormone , enzyme , biochemistry

Prostaglandins (PGs) produced within ovarian follicles in response to the ovulatory gonadotropin surge are essential for follicle rupture and oocyte release. Arachidonic acid, the common precursor for PG synthesis, is cleaved from membrane phospholipids via the activity of phospholipase A2 (PLA2).

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