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The Na+/I- symporter (NIS) has been proposed to serve as an imaging reporter gene to optimize vector delivery, monitor therapeutic gene expression, and map the tissue/organ sites of repopulated progenitor cells in vivo. In addition, NIS can serve as a therapeutic gene to facilitate targeted radionuclide therapy for various cancers.

the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism

Cell Surface Targeting Accounts for the Difference in Iodide Uptake Activity between Human Na+/I−Symporter and Rat Na+/I−Symporter