Cell Surface Targeting Accounts for the Difference in Iodide Uptake Activity between Human Na+/I−Symporter and Rat Na+/I−Symporter | Zendy

Zhaoxia Zhang | Zendy; Yuyu Liu | Zendy; Sissy Jhiang | Zendy

Open Access

Cell Surface Targeting Accounts for the Difference in Iodide Uptake Activity between Human Na⁺/I⁻Symporter and Rat Na⁺/I⁻Symporter

Author(s) -

Zhaoxia Zhang,

Yuyu Liu,

Sissy Jhiang

Publication year - 2005

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2005-0895

Subject(s) - sodium iodide symporter , symporter , context (archaeology) , genetic enhancement , reporter gene , cancer research , in vivo , chemistry , microbiology and biotechnology , gene expression , biology , gene , biochemistry , genetics , transporter , paleontology

The Na+/I- symporter (NIS) has been proposed to serve as an imaging reporter gene to optimize vector delivery, monitor therapeutic gene expression, and map the tissue/organ sites of repopulated progenitor cells in vivo. In addition, NIS can serve as a therapeutic gene to facilitate targeted radionuclide therapy for various cancers.

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