Increased Transcription and Increased Messenger Ribonucleic Acid (mRNA) Stability Contribute to Increased GATA6 mRNA Abundance in Polycystic Ovary Syndrome Theca Cells | Zendy

Clement Ho | Zendy; Jennifer R. Wood | Zendy; Douglas R. Stewart | Zendy; Kathryn G. Ewens | Zendy; Wendy Ankener | Zendy; Jessica K. Wickenheisser | Zendy; Velen L. Nelson-DeGrave | Zendy; Zhibing Zhang | Zendy; Richard S. Legro | Zendy; Andrea Dunaif | Zendy; Jan M. McAllister | Zendy; Richard S. Spielman | Zendy; Jerome F. Strauss | Zendy

Open Access

Increased Transcription and Increased Messenger Ribonucleic Acid (mRNA) Stability Contribute to Increased GATA6 mRNA Abundance in Polycystic Ovary Syndrome Theca Cells

Author(s) -

Clement Ho,

Jennifer R. Wood,

Douglas R. Stewart,

Kathryn G. Ewens,

Wendy Ankener,

Jessica K. Wickenheisser,

Velen L. Nelson-DeGrave,

Zhibing Zhang,

Richard S. Legro,

Andrea Dunaif,

Jan M. McAllister,

Richard S. Spielman,

Jerome F. Strauss

Publication year - 2005

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2005-0890

Subject(s) - messenger rna , polycystic ovary , theca , transcription (linguistics) , ovary , biology , medicine , microbiology and biotechnology , endocrinology , chemistry , genetics , gene , insulin , insulin resistance , linguistics , philosophy

Polycystic ovary syndrome (PCOS) theca cells secrete increased levels of androgens. The mRNA and protein levels of the transcription factor GATA6, which regulates expression of several steroidogenic enzymes, are increased in PCOS theca cells. Thus, GATA6 is a PCOS candidate gene.

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