Open AccessInhibition of Cortisol Biosynthesis Decreases Circulating Leptin Levels in Obese Humans
Author(s) -
Samuel DagogoJack,
Gunjan Tykodi,
Indira Umamaheswaran
Publication year - 2005
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2005-0803
Subject(s) - leptin , endocrinology , medicine , biosynthesis , obesity , biology , biochemistry , enzyme
Glucocorticoids increase both appetite and leptin secretion; the hyperleptinemic effect might be a counterregulatory response to the orexigenic effect of glucocorticoids. However, the effect of glucocorticoid inhibition on leptin production has not been reported.
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