Effects of Physiological Leptin Administration on Markers of Inflammation, Platelet Activation, and Platelet Aggregation during Caloric Deprivation | Zendy

Bridget Canavan | Zendy; Raneem O. Salem | Zendy; Sunita Schurgin | Zendy; Polyxeni Koutkia | Zendy; Izabella Lipinska | Zendy; Michael Laposata | Zendy; Steven Grinspoon | Zendy

Open Access

Effects of Physiological Leptin Administration on Markers of Inflammation, Platelet Activation, and Platelet Aggregation during Caloric Deprivation

Author(s) -

Bridget Canavan,

Raneem O. Salem,

Sunita Schurgin,

Polyxeni Koutkia,

Izabella Lipinska,

Michael Laposata,

Steven Grinspoon

Publication year - 2005

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2005-0780

Subject(s) - leptin , medicine , endocrinology , inflammation , context (archaeology) , platelet , platelet activation , cytokine , platelet aggregation , proinflammatory cytokine , caloric theory , adipocyte , obesity , biology , adipose tissue , paleontology

Leptin is a nutritionally regulated adipocyte-derived cytokine. Previous studies in obese patients have demonstrated increased inflammatory markers and increased platelet aggregation in association with leptin. However, the effects of leptin administration on markers of inflammation and platelet aggregation in a human model of undernutrition have not previously been studied.

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