Role of CD95-Mediated Adipocyte Loss in Autoimmune Lipodystrophy
Author(s) -
Pamela FischerPosovszky,
Helge Hebestreit,
Albert K. Hofmann,
Gudrun Strauß,
Peter Möller,
KlausMichael Debatin,
Martin Wabitsch
Publication year - 2006
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2005-0737
Subject(s) - adipose tissue , lipodystrophy , adipocyte , medicine , endocrinology , adiponectin , inflammation , biology , insulin resistance , immunology , insulin , human immunodeficiency virus (hiv) , viral load , antiretroviral therapy
Lipodystrophies are rare disorders characterized by the selective loss of adipose tissue. Metabolic complications increase in severity with the extent of fat loss. In some forms of acquired lipodystrophy, the loss of fat is suggested to be a result of autoimmune destruction of adipocytes. Here, the pathogenic mechanism is still poorly understood.
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