Third- or Second-Generation Parathyroid Hormone Assays: A Remaining Debate in the Diagnosis of Primary Hyperparathyroidism | Zendy

Philippe Boudou | Zendy; Fidaa Ibrahim | Zendy; Catherine Cormier | Zendy; Almécinda Chabas | Zendy; E. Sarfati | Zendy; JeanClaude Souberbielle | Zendy

Open Access

Third- or Second-Generation Parathyroid Hormone Assays: A Remaining Debate in the Diagnosis of Primary Hyperparathyroidism

Author(s) -

Philippe Boudou,

Fidaa Ibrahim,

Catherine Cormier,

Almécinda Chabas,

E. Sarfati,

JeanClaude Souberbielle

Publication year - 2005

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2005-0715

Subject(s) - primary hyperparathyroidism , parathyroid hormone , medicine , hyperparathyroidism , endocrinology , calcium

Since the demonstration that the second-generation PTH assays, also called intact PTH assays, recognize a non-1-84 PTH fragment in addition to the intact 1-84 PTH, new PTH assays defined as third-generation assays have been commercialized. Two previous studies aimed at evaluating whether these third-generation PTH assays improved the diagnostic sensitivity for primary hyperparathyroidism (PHPT), but they yielded opposite results.

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