Extracellular Matrix and Hormones Modulate DAX-1 Localization in the Human Fetal Adrenal Gland
Author(s) -
MarieClaude Battista,
Mélissa Otis,
Mylène Côté,
Andréane Laforest,
Michael Peter,
Enzo Lalli,
Nicole GalloPayet
Publication year - 2005
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2005-0666
Subject(s) - fibronectin , extracellular matrix , microbiology and biotechnology , cytoplasm , nuclear localization sequence , biology , extracellular , adrenal cortex , adrenal gland , fetus , medicine , endocrinology , subcellular localization , hormone , angiotensin ii , genetics , pregnancy , blood pressure
The orphan nuclear receptor DAX-1 is essential for human adrenal cortex development and functions as a transcriptional repressor of multiple genes implicated in steroidogenic pathways.
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