Expression of the Antiapoptotic Gene Seladin-1 and Octreotide-Induced Apoptosis in Growth Hormone-Secreting and Nonfunctioning Pituitary Adenomas | Zendy

Paola Luciani | Zendy; Stefania Gelmini | Zendy; Emanuele Ferrante | Zendy; Andrea Lania | Zendy; Susanna Benvenuti | Zendy; Silvana Baglioni | Zendy; Giovanna Mantovani | Zendy; Ilaria Cellai | Zendy; Franco Ammannati | Zendy; Anna Spada | Zendy; Mario Serio | Zendy; Alessandro Peri | Zendy

Open Access

Expression of the Antiapoptotic Gene Seladin-1 and Octreotide-Induced Apoptosis in Growth Hormone-Secreting and Nonfunctioning Pituitary Adenomas

Author(s) -

Paola Luciani,

Stefania Gelmini,

Emanuele Ferrante,

Andrea Lania,

Susanna Benvenuti,

Silvana Baglioni,

Giovanna Mantovani,

Ilaria Cellai,

Franco Ammannati,

Anna Spada,

Mario Serio,

Alessandro Peri

Publication year - 2005

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2005-0633

Subject(s) - medicine , endocrinology , apoptosis , pituitary adenoma , pituitary gland , somatostatin , context (archaeology) , pituitary neoplasm , biology , gene expression , adenoma , cancer research , hormone , gene , genetics , paleontology

Seladin-1 (from selective Alzheimer's disease indicator-1) is a recently discovered gene that has been found to be down-regulated in brain regions affected by Alzheimer's disease. Seladin-1 effectively protects neurons against beta-amyloid-mediated toxicity and prevents apoptosis via inhibition of the activation of caspase-3, a key mediator of the apoptotic cascade. Although seladin-1 is expressed in the pituitary gland, no study addressed the expression or the function of this gene in pituitary adenomas.

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