Obese Subjects Carrying the 11482G>A Polymorphism at the Perilipin Locus Are Resistant to Weight Loss after Dietary Energy Restriction | Zendy

Dolores Corella | Zendy; Lu Qi | Zendy; José V. Sorlí | Zendy; Diego Godoy | Zendy; Olga Portolés | Zendy; Óscar Coltell | Zendy; Andrew S. Greenberg | Zendy; José M. Ordovás | Zendy

Open Access

Obese Subjects Carrying the 11482G>A Polymorphism at the Perilipin Locus Are Resistant to Weight Loss after Dietary Energy Restriction

Author(s) -

Dolores Corella,

Lu Qi,

José V. Sorlí,

Diego Godoy,

Olga Portolés,

Óscar Coltell,

Andrew S. Greenberg,

José M. Ordovás

Publication year - 2005

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2005-0576

Subject(s) - perilipin , weight loss , obesity , medicine , genotype , minor allele frequency , endocrinology , body mass index , allele , adipose tissue , biology , allele frequency , genetics , lipolysis , gene

Dietary treatment of obesity could be improved if predictive information about the individual's genetic response to diet was available. Adipose tissue has been the focus of efforts to identify candidate genes. Perilipin is a major protein found in adipocytes, and perilipin knockout mice are lean and resistant to diet-induced obesity.

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